The first colonists to leave Britain for America settle in Virginia, full of hope for their new home, and dreaming of riches. But after just six months, 80 of the 100 were dead. The received wisdom is that they died of malaria or another disease. But, recent exhumations reveal a surprising discovery. The bodies contain high levels of arsenic. Were they poisoned? And could the culprit have been a Catholic intent on stopping the Protestants from colonizing the New World?

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